Autor(es): Schlenke Peter

Resumo: Nowadays patients receiving blood components are exposed to much less transfusion-transmitted infectious diseases than three decades before when among others HIV was identified as causative agent for the acquired immunodeficiency syndrome - the transmission by blood or coagulation factors became evident. Since that time the implementation of measures for risk prevention - safety precaution was socially - politically accepted. Currently emerging pathogens like arboviruses - the well-known bacterial contamination of platelet concentrates still remain major concerns of blood safety with important clinical consequences, but very rarely with fatal outcome for the blood recipient. In contrast to the well-established pathogen inactivation strategies for fresh frozen plasma using the solvent-detergent procedure or methylene blue - visible light, the bench-to-bedside translation of novel pathogen inactivation technologies for cell-containing blood components such as platelets - red blood cells are still underway. This review summarizes the pharmacological/toxicological assessment - the inactivation efficacy against viruses, bacteria, - protozoa of each of the currently available pathogen inactivation technologies - highlights the impact of the results obtained from several r-omized clinical trials - hemovigilance data. Until now in some European countries pathogen inactivation technologies are in in routine use for single-donor plasma - platelets. The invention - adaption of pathogen inactivation technologies for red blood cell units - whole blood donations suggest the universal applicability of these technologies - foster a paradigm shift in the manufacturing of safe blood.

Palavras-Chave: Bacteria; Blood safety; Chikungunya virus; Dengue virus; Hemovigilance; Pathogen inactivation; Platelet concentrates; Protozoa; Randomized clinical trial; Red blood cells; West Nile virus

Imprenta: Transfusion Medicine and Hemotherapy, v. 41, n. 4, p. 309-325, 2014

Identificador do objeto digital: 10.1159/000365646

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cell ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Serology ; Chikungunya virus - Viral infections ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Dengue

Data de publicação: 2014

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