Autor(es): Govindarajan Marimuthu, Sivakumar Rajamohan

Resumo: Several diseases are associated to the mosquito-human interaction. Mosquitoes are the carriers of severe - well-known illnesses such as malaria, arboviral encephalitis, dengue fever, chikungunya fever, West Nile virus - yellow fever. These diseases produce significant morbidity - mortality in humans - livestock around the world. The present investigation was undertaken to study the ovicidal, larvicidal - adulticidal activities of crude hexane, ethyl acetate, benzene, chloroform - methanol extracts of root of Asparagus racemosus were assayed for their toxicity against three important vector mosquitoes, viz., Culex quinquefasciatus, Aedes aegypti - Anopheles stephensi (Diptera: Culicidae). The mean percent hatchability of the eggs was observed after 48 h post-treatment. The percent hatchability was inversely proportional to the concentration of extract - directly proportional to the eggs. All the five solvent extracts showed moderate ovicidal activity; however, the methanol extract showed the highest ovicidal activity. The methanol extract of Asparagus racemosus against Culex quinquefasciatus, Aedes aegypti - Anopheles stephensi exerted 100% mortality (zero hatchability) at 375, 300 - 225 ppm, respectively. Control eggs showed 99-100% hatchability. The larval mortality was observed after 24 h of exposure. All extracts showed moderate larvicidal effects; however, the highest larval mortality was found in methanol extract of root of Asparagus racemosus against the larvae of Culex quinquefasciatus, Aedes aegypti - Anopheles stephensi with the LC50 - LC90 values were 115.13, 97.71 - 90.97 ppm - 210.96, 179.92, - 168.82 ppm, respectively. The adult mortality was observed after 24 h recovery period. The plant crude extracts showed dose-dependent mortality. At higher concentrations, the adult showed restless movement for some times with abnormal wagging - then died. Among the extracts tested, the highest adulticidal activity was observed in methanol extract against Anopheles stephensi followed by Aedes aegypti - Culex quinquefasciatus with the LD50 - LD90 values were 120.44, 135.60, - 157.71 ppm - 214.65, 248.35, - 290.95 ppm, respectively. No mortality was recorded in the control. The finding of the present investigation revealed that the root extract of Asparagus racemosus possess remarkable ovicidal, larvicidal - adulticidal activity against medically important vector mosquitoes - this is the low cost - ideal eco-friendly approach for the control of mosquitoes. This is the first report on the mosquito ovicidal, larvicidal - adulticidal activities of the reported Asparagus racemosus root.

Imprenta: Parasitology Research, v. 113, n. 4, p. 1435-1449, 2014

Identificador do objeto digital: 10.1007/s00436-014-3784-1

Descritores: Chikungunya virus - Cell ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Ovicida ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue

Data de publicação: 2014

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