Orally co-Infected Aedes albopictus from La Reunion Island, Indian Ocean, can deliver both dengue and chikungunya infectious viral particles in their saliva

Autor(es): Vazeille Marie, Mousson Laurence, Martin Estelle, Failloux Anna-Bella


Resumo: First described in humans in 1964, reports of co-infections with dengue (DENV) - chikungunya (CHIKV) viruses are increasing, particularly after the emergence of chikungunya (CHIK) in the Indian Ocean in 2005-2006 due to a new variant highly transmitted by Aedes albopictus. In this geographic area, a dengue (DEN) outbreak transmitted by Ae. albopictus took place shortly before the emergence of CHIK - co-infections were reported in patients. A co-infection in humans can occur following the bite of two mosquitoes infected with one virus or to the bite of a mosquito infected with two viruses. Co-infections in mosquitoes have never been demonstrated in the field or in the laboratory. Thus, we question about the ability of a mosquito to deliver infectious particles of two different viruses through the female saliva. We orally exposed Ae. albopictus from La Reunion Isl- with DENV-1 - CHIKV isolated respectively during the 2004-2005 - the 2005-2006 outbreaks on this same isl-. We were able to show that Ae. albopictus could disseminate both viruses - deliver both infectious viral particles concomitantly in its saliva. We also succeeded in inducing a secondary infection with CHIKV in mosquitoes previously inoculated with DENV-1. In this study, we underline the ability of Ae. albopictus to be orally co-infected with two different arboviruses - furthermore, its capacity to deliver concomitantly infectious particles of CHIKV - DENV in saliva. This finding is of particular concern as Ae. albopictus is still exp-ing its geographical range in the tropical as well as in the temperate regions. Further studies are needed to try to elucidate the molecular/cellular basis of this phenomenon.


Imprenta: PLoS Neglected Tropical Diseases, v. 4, n. 6, p. e706, 2010


Identificador do objeto digital: 10.1371/journal.pntd.0000706


Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Dengue ; Chikungunya virus - Public health


Data de publicação: 2010