Ocular involvement associated with an epidemic outbreak of Chikungunya virus infection
Autor(es): Lalitha Prajna, Rathinam Sivakumar, Banushree Krishnadas, Maheshkumar Shanmugam, Vijayakumar Rajendran, Sathe Padmakar
Resumo: To study the range of ocular symptoms in a cohort of patients with chikungunya infection. Retrospective, observational case series. Patients attending a tertiary eye care hospital in South India were included in the study. We included adult patients with serologically confirmed chikungunya virus infection who received clinical care at the Aravind Eye Hospital, Madurai, South India. They were assessed for demographic characteristics, ocular symptoms, laboratory parameters, - chikungunya virus infection severity. Patients underwent a complete ophthalmologic examination that included visual acuity, slit-lamp examination, - indirect funduscopic examination. Visual outcome at the end of three months was the main outcome measure. The charts of 37 patients were analyzed based on the clinical picture - the serologic results. Forty patients were included as controls - tested negative. There were 21 males - 16 females with a mean age of 44.17 years. The main ocular symptoms included granulomatous - nongranulomatous anterior uveitis, optic neuritis retrobulbar neuritis, - dendritic lesions. Of the 26 patients who were followed up for three months, the visual acuity improved in 11 patients (42.3%), remained the same in 12 patients (46.15%), - worsened in three patients (11.5%). The main ocular manifestation associated with the recent epidemic outbreak of chikungunya virus infection in South India included granulomatous - nongranulomatous anterior uveitis, optic neuritis, retrobulbar neuritis, - dendritic lesions. The visual prognosis generally was good, with most patients recovering good vision. Further studies are needed to underst- the pathogenesis of this disease.
Imprenta: American Journal of Ophthalmology, v. 144, n. 4, p. 552-556, 2007
Identificador do objeto digital: 10.1016/j.ajo.2007.06.002
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya virus - Clinical examination ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2007
