Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India
Autor(es): Singh Priyanka, Mittal Veena, Rizvi Moshahid A, Bhattacharya Dipesh, Chhabra Mala, Rawat Devendra S, Ichhpujani Rattan L, Chauhan Lakhvir S, Rai Arvind
Resumo: Re-emergence of chikungunya virus in South India after a gap of 32 years in 2006 affected over a million people in the Indian subcontinent. We kept a close vigil over the emerging trend of this virus between 2006-2010 with a view to establish the identity of the circulating genotype(s) - to determine the route of virus transmission in different parts of India. Nucleotide sequencing of the E1 gene region from 36 strains of chikungunya virus from three states in northern India was performed for this present study. Forty-four previously reported E1 sequences, retrieved from the global genome data base were used for making a phylogenetic tree. BLAST search revealed 99% homology of the northern Indian strains of the 2006-2010 outbreak with the Reunion Isl- isolates of 2006. Northern Indian strains of this study clustered with the East Central South African (ECSA) genotype. Findings indicate that the currently circulating strain of chikungunya virus in northern India had its origin from the 2006 epidemic strain of South India that moved toward northern India via the western central India between 2006-2010 in a phased manner with dominance of the ECSA genotype - not the Asian genotype.
Imprenta: Journal of Infection in Developing Countries, v. 6, n. 7, p. 563-571, 2012
Identificador do objeto digital: 10.3855/jidc.2136
Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - DNA ; Chikungunya virus - Genome ; Chikungunya virus - Pathogenesis ; Chikungunya virus - RNA ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2012
