Autor(es): Chandak Nitin H, Kashyap Rajpal S, Kabra Dinesh, Karandikar Poornima, Saha Sonali S, Morey Shweta H, Purohit Hemant J, Taori Girdhar M, Daginawala Hatim F

Resumo: In May 2006, there was a large Chikungunya virus infection (CHIKV) outbreak in the Nagpur district of Maharashtra, a province in western India. Usually, CHIKV is a self-limiting febrile illness. However, neurological complications have been described infrequently. To study the clinical characteristics of various neurological complications associated with CHIKV infections. Patients with neurological complications following CHIKV infection during the outbreak were the subjects of the study. On the basis of clinical features - investigative findings, patients were grouped into various neurological syndromes: Encephalitis, myelopathy, peripheral neuropathy, myeloneuropathy, - myopathy. Cerebrospinal fluid (CSF) samples were also collected for biochemical - serological studies. Of the 300 patients with CHIKV infection seen during the study period, June-December 2006, 49 (16.3%) [M : F: 42:7] had neurological complications. The neurological complications included: Encephalitis (27, 55%), myelopathy (7, 14% ), peripheral neuropathy (7, 14%), myeloneuropathy (7, 14%), - myopathy (1, 2%). Reverse Transcriptase polymerase chain reaction (RT-PCR) - real-time PCR was positive in the CSF in 16% - 18%, respectively. Recent CHIKV infection was associated with various neurological complications, suggesting neurotropic nature of the virus. The outcome of the neurological complications is likely to be good.

Palavras-Chave: Chikungunya; Neurological complications; Encephalitis; Myelitis; Peripheral neuropathy; Cerebrospinal fluid

Imprenta: Neurology India, v. 57, n. 2, p. 177-180, 2009

Identificador do objeto digital: 10.4103/0028-3886.51289

Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - Biosynthesis ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya virus - Real Time PCR ; Chikungunya virus - RT-PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2009

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