Mouse models for Chikungunya virus: deciphering immune mechanisms responsible for disease and pathology
Autor(es): Teo Teck-Hui, Lum Fok-Moon, Lee Wendy W L, Ng Lisa F P
Resumo: Chikungunya virus (CHIKV), an alphavirus, has been responsible for large epidemic outbreaks with serious economic - social impact during the last 6 years. Transmitted by Aedes mosquitoes, it causes Chikungunya fever, an acute illness in patients with a stooped posture often associated with chronic - incapacitating arthralgia. The unprecedented re-emergence has stimulated renewed interest in CHIKV. This review discusses the advantages - disadvantages of different animal models for CHIKV infections - their importance to study the role of the immune system in different pathologies caused by CHIKV. We also reveal how such studies still present a difficult challenge, but are indispensible for mechanistic studies to further underst- the pathophysiology of CHIKV infections.
Palavras-Chave: Chikungunya virus; Alphavirus; Infection; Immunity; Pathogenesis; Mouse models
Imprenta: Immunologic Research, v. 53, n. 1-3, p. 136-147, 2012
Identificador do objeto digital: 10.1007/s12026-012-8266-x
Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2012
