Molecular epidemiology of Chikungunya virus in Malaysia since its first emergence in 1998
Autor(es): Chem Y K, Zainah S, Berendam S J, Rogayah T A R Tengku, Khairul A H, Chua K B
Resumo: Malaysia experienced the first outbreak of chikungunya (CHIK) in Klang in late 1998 due to CHIK virus of Asian genotype. The CHIK virus of Asian genotype reemerged causing outbreak in Bangan Panchor, Perak in March 2006. CHIK virus of Central/East African genotype was first detected from a patient who returned from India in August 2006. In December 2006, CHIK virus of Central/East African genotype was re-introduced into Malaysia from India - caused an outbreak in Kinta district, Perak but was successfully controlled following an early detection - institution of intensive vector control measures. In late April 2008, CHIK virus of Central/East African genotype was laboratory confirmed as the cause of CHIK outbreak in Johore which spread to other parts of Malaysia by August 2008. Phylogenetic analysis based on the 254-bp fragment of the virus envelope protein gene as the genetic marker showed that three different strains of CHIK virus of Central/East African genotype were introduced into Malaysia on three separate occasions from 2006 to 2008. The strain that was introduced into Johor state was responsible for its subsequent spread to other parts of Malaysia, inclusive of Sarawak.
Palavras-Chave: Chikungunya; Molecular epidemiology; Malaysia
Imprenta: The Medical Journal of Malaysia, v. 65, n. 1, p. 31-35, 2010
Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - Molecular structure ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2010
