Mechanisms of innate immune evasion in re-emerging RNA viruses
Autor(es): Ma Daphne Y, Suthar Mehul S
Resumo: Recent outbreaks of Ebola, West Nile, Chikungunya, Middle Eastern Respiratory - other emerging/re-emerging RNA viruses continue to highlight the need to further underst- the virus-host interactions that govern disease severity - infection outcome. As part of the early host antiviral defense, the innate immune system mediates pathogen recognition - initiation of potent antiviral programs that serve to limit virus replication, limit virus spread - activate adaptive immune responses. Concordantly, viral pathogens have evolved several strategies to counteract pathogen recognition - cell-intrinsic antiviral responses. In this review, we highlight the major mechanisms of innate immune evasion by emerging - re-emerging RNA viruses, focusing on pathogens that pose significant risk to public health.
Imprenta: Current Opinion in Virology, v. 12, p. 26-37, 2015
Identificador do objeto digital: 10.1016/j.coviro.2015.02.005
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Cytokines ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2015
