Autor(es): Nitatpattana Narong, Kanjanopas Kobkan, Yoksan Sutee, Satimai Wichai, Vongba Narong, Langdatsuwan Sasiporn, Nakgoi Khajornpong, Ratchakum Supot, Wauquier Nadia, Souris Marc, Auewarakul Prasert, Gonzalez Jean-Paul

Resumo: Chikungunya virus (CHIKV) outbreak recurrences in Thail- are unpredictable - separated by unexplained - often long silent epidemiological periods that can last for several years. These silent periods could be explained in part by the fact that infection with one CHIKV strain confers lasting natural immunity, even against other CHIKV strains. In this study we evaluated the persistence of CHIKV-specific neutralizing antibodies in the population of Chumpae District, Khon Kaen Province, nineteen years after a CHIKV outbreak occurred in the same area in 1991. Overall 39% (44/111) of 111 former patients had neutralizing antibodies reacting against CHIKV ECSA strain. Consistently high titers of neutralizing antibodies were found in 75% (33/44) of all positively-reacting sera, 70% of which (23/33) were collected from individuals amongst the >60 years old age group. Although the prevalence found in Pong Haeng village (70%) was significantly higher than the prevalence detected in the Nong Thum village (14%), control study villages without known previous Chikungunya epidemics had a high Chikungunya neutralizing antibody prevalence (65%). More than one-third of the pre-exposed population had persisting natural immunity that was more likely boosted by recent - repetitive exposure to the emerging ECSA CHIKV in Thail-. Also, Chikungunya virus appears to largely circulate in the country with a great variability appears between villages or area probably associated with the vector abundance - efficiency. Altogether these results show a potential for a lifelong immunity against CHIKV. Given the rapid spread of the highly pathogenic ECSA strain in Southern Thail-, the development of CHIK vaccine is strongly recommended.

Palavras-Chave: Chikungunya virus; Cross-neutralization; Thailand

Imprenta: Virology Journal, v. 11, p. 183, 2014

Identificador do objeto digital: 10.1186/1743-422X-11-183

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology

Data de publicação: 2014

INDICADORES

ACESSO