Long-term arthralgia after Mayaro virus infection correlates with sustained pro-inflammatory cytokine response
Autor(es): Santiago Felix W, Halsey Eric S, Siles Crystyan, Vilcarromero Stalin, Guevara Carolina, Silvas Jesus A, Ramal Cesar, Ampuero Julia S, Aguilar Patricia V
Resumo: Mayaro virus (MAYV), an alphavirus similar to chikungunya virus (CHIKV), causes an acute debilitating disease which results in the development of long-term arthralgia in more than 50% of infected individuals. Currently, the immune response - its role in the development of MAYV-induced persistent arthralgia remain unknown. In this study, we evaluated the immune response of individuals with confirmed MAYV infection in a one-year longitudinal study carried out in Loreto, Peru. We report that MAYV infection elicits robust immune responses that result in the development of a strong neutralizing antibody response - the secretion of pro-inflammatory immune mediators. The composition of these inflammatory mediators, in some cases, differed to those previously observed for CHIKV. Key mediators such as IL-13, IL-7 - VEGF were strongly induced following MAYV infection - were significantly increased in subjects that eventually developed persistent arthralgia. Although a strong neutralizing antibody response was observed in all subjects, it was not sufficient to prevent the long-term outcomes of MAYV infection. This study provides initial immunologic insight that may eventually contribute to prognostic tools - therapeutic treatments against this emerging pathogen.
Imprenta: PLoS Neglected Tropical Diseases, v. 9, n. 10, p. e0004104, 2015
Identificador do objeto digital: 10.1371/journal.pntd.0004104
Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Immune response ; Chikungunya virus - Immune response ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus
Data de publicação: 2015
