Autor(es): Galatas Beatriz, Ly Sowath, Duong Veasna, Baisley Kathy, Nguon Kunthy, Chan Siam, Huy Rekol, Ly Sovann, Sorn Sopheak, Som Leakhann, Buchy Philippe, Tarantola Arnaud

Resumo: The East/Central/South African genotype of Chikungunya virus with the E1-A226V mutation emerged in 2011 in Cambodia - spread in 2012. An outbreak of 190 cases was documented in Trapeang Roka, a rural village. We surveyed 425 village residents within 3-4 weeks after the outbreak, - determined the sensitivity - specificity of case definitions - factors associated with infection by CHIKV. Self-reported clinical presentation consisted mostly of fever, rash - arthralgia. The presence of all three clinical signs or symptoms was identified as the most sensitive (67%) - specific (84%) self-reported diagnostic clinical indicator compared to biological confirmation by MAC-ELISA or RT-PCR used as a reference. Having an indoor occupation was associated with lower odds of infection compared with people who remained at home (adjOR 0.32, 95%CI 0.12-0.82). In contrast with findings from outbreaks in other settings, persons aged above 40 years were less at risk of CHIKV infection, likely reflecting immune protection acquired when Chikungunya circulated in Cambodia before the Khmer Rouge regime in 1975. In view of the very particular history of Cambodia, our epidemiological data from Trapeang Roka are the first to support the persistence of CHIKV antibodies over a period of 40 years.

Imprenta: PLoS Neglected Tropical Diseases, v. 10, n. 1, p. e0004281, 2016

Identificador do objeto digital: 10.1371/journal.pntd.0004281

Descritores: Chikungunya virus - Antibodies ; Chikungunya virus - RT-PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever

Data de publicação: 2016

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