Autor(es): Chusri Sarunyou, Siripaitoon Pisud, Silpapojakul Kachornsak, Hortiwakul Thanaporn, Charernmak Boonsri, Chinnawirotpisan Piyawan, Nisalak Ananda, Thaisomboonsuk Butsaya, Klungthong Chonticha, Gibbons Robert V, Jarman Richard G

Resumo: The Indian Ocean chikungunya epidemic re-emerged in Thail- in August 2008. Forty-five adults with laboratory-confirmed chikungunya in Songkhla province, Thail- were clinically assessed - serially bled throughout the acute - convalescent phase of the disease. Patient symptoms, antibody responses, - viral kinetics were evaluated using observational assessments, polymerase chain reaction (PCR), - serological assays. All subjects experienced joint pain with 42 (93%) involving multiple joints; the interphalangeal most commonly affected in 91% of the subjects. The mean duration of joint pain was 5.8 days, 11 (25%) experiencing discomfort through the duration of the study. Rash was observed in 37 (82%) subjects a mean 3.5 days post onset of symptoms. Patents were positive by PCR for a mean of 5.9 days with sustained peak viral load through Day 5. The IgM antibodies appeared on Day 4 - peaked at Day 7 - IgG antibodies first appeared at Day 5 - rose steadily through Day 24.

Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 90, n. 3, p. 410-417, 2014

Identificador do objeto digital: 10.4269/ajtmh.12-0681

Descritores: Chikungunya virus - DNA ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya virus - Serological diagnosis ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology

Data de publicação: 2014

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