International diagnostic accuracy study for the serological detection of Chikungunya virus infection
Autor(es): Niedrig M, Zeller H, Schuffenecker I, Drosten C, Emmerich P, Rumer L, Donoso-Mantke O
Resumo: External quality assurance for serological detection of chikungunya virus infection was performed to assess the diagnostic quality of expert laboratories. Of 30 participants, only six correctly analysed all reference samples with their respective tests. Thirteen laboratories gave at least 85% correct results, - 11 laboratories 75% or less. IgM antibodies were detected less frequently than IgG antibodies (p <0.001). The study provides information on the quality of different serological tests - indicates that most of the participants need to improve the sensitivity of their assays, in particular to detect IgM antibodies more reliably - be able to detect acute infections adequately.
Palavras-Chave: Chikungunya fever; Emerging viral infection; External quality assurance; Serology; Virus diagnostic
Imprenta: Clinical Microbiology and Infection, v. 15, n. 9, p. 880-884, 2009
Identificador do objeto digital: 10.1111/j.1469-0691.2009.02851.x
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Serology ; Chikungunya virus - Viral infections ; Chikungunya virus - Serological diagnosis ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Immunology
Data de publicação: 2009
