Interferon production in chick embryo cells: I. Production by ultraviolet-inactivated virus
Autor(es): Burke D C, Buchan A
Resumo: Chick embryo cells, after treatment with ultraviolet-inactivated influenza virus (UV-MEL), produce interferon after a lag of about 10 hours. The interferon is rapidly released from the cells, and the titre in the medium increases almost linearly with time for about 40 hours, after which the rate of production gradually decreases. Cells that had been treated with UV-MEL could not be restimulated to produce interferon. Exposure of the cells to UV-MEL reduces the net rate of protein and RNA synthesis of the cells. This effect is probably a toxic action of the virus, unrelated to interferon production.
Imprenta: Virology, v. 26, p. 28-35, 1965
Identificador do objeto digital: 10.1016/0042-6822(65)90022-X
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Cytokines ; Chikungunya virus - Serology ; Chikungunya virus - Serology ; Chikungunya Virus - Virus
Data de publicação: 1965
