Inactivation and elimination of viruses during preparation of human intravenous immunoglobulin
Autor(es): Uemura Y, Yang Y H, Heldebrant C M, Takechi K, Yokoyama K
Resumo: We report here the results of our evaluation of virus inactivation during the manufacturing steps of two intravenous immunoglobulin (IGIV) preparations. Virus inactivation -/or removal by processing steps, such as ethanol fractionation - polyethylene glycol precipitation, - deliberate virucidal steps, such as solvent/detergent treatment - pasteurization, were tested on a variety of human pathogenic - experimental model viruses, including human immunodeficiency, Hepatitis C, Mumps, Vaccinia, Chikungunya, Vesicular Stomatitis, Sindbis, - ECHO viruses. All viruses were successfully inactivated -/or eliminated by the processing steps studied. In some cases, however, multiple steps were required. We conclude that the incorporation of steps deliberately designed to inactivate or remove viruses during the production of IGIV provides an extra measure of viral safety.
Imprenta: Vox Sanguinis, v. 67, n. 3, p. 246-254, 1994
Identificador do objeto digital: 10.1111/j.1423-0410.1994.tb01246.x
Descritores: Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Public health
Data de publicação: 1994
