Impaired quality of life after Chikungunya virus infection: A 2-year follow-up study
Autor(es): Couturier Elisabeth, Guillemin Francis, Mura Marie, Léon Lucie, Virion Jean-Marc, Letort Marie-José, De Valk Henriette, Simon Fabrice, Vaillant Véronique
Resumo: To measure the frequency of - risk factors for rheumatic manifestations after chikungunya virus (CHIKV) infection - to assess their impact on quality of life (QoL). In a cohort study among 509 cases diagnosed in France, demographic - clinical characteristics were collected at baseline, - QoL status by 36-item short-form health survey (SF-36), a short form of the Arthritis Impact Measurement Scales 2 (AIMS2-SF) - General Health Questionnaire (GHQ-12) at follow-up. SF-36 scores were compared with population norms. Factors associated with QoL were identified in multivariate linear regression models. A total of 391 (77%) patients participated (53.5% female, mean age 50.2 years). Median time from onset at follow-up was 23.4 months. Among 176 recovered patients, a shorter duration of symptoms was observed in younger age groups - male patients. The probability of full recovery at 1 year was 0.39. Those not recovered were older, had more comorbidities - a longer acute stage with joint swelling. Scores of physical - mental components of the SF-36 - GHQ-12 were low. The AIMS2-SF was affected mainly in symptoms, psychological - social dimensions. Recovered patients did not differ significantly from age- - gender-matched population SF-36 norms. Older age (P = 0.01-0.002) was associated with lower SF-36 scores. Other factors associated with lower SF-36, lower GHQ12 scores - higher AIMS2-SF dimensions were lack of recovery (P = 0.017 to <0.0001), presence of comorbidity (P = 0.005 to <0.0001) - a longer duration of acute stage (P = 0.047 to <0.0001). Medical follow-up with special attention to comorbidity providing information on possible chronic symptoms - giving support for potential depression - anxiety are recommended.
Palavras-Chave: Chikungunya infection; Quality of life; France
Imprenta: Rheumatology, v. 51, n. 7, p. 1315-1322, 2012
Identificador do objeto digital: 10.1093/rheumatology/kes015
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2012
