Autor(es): Ng Lisa F P, Chow Angela, Sun Yong-Jiang, Kwek Dyan J C, Lim Poh-Lian, Dimatatac Frederico, Ng Lee-Ching, Ooi Eng-Eong, Choo Khar-Heng, Her Zhisheng, Kourilsky Philippe, Leo Yee-Sin

Resumo: Little is known about the immunopathogenesis of Chikungunya virus. Circulating levels of immune mediators - growth factors were analyzed from patients infected during the first Singaporean Chikungunya fever outbreak in early 2008 to establish biomarkers associated with infection -/or disease severity. Adult patients with laboratory-confirmed Chikungunya fever infection, who were referred to the Communicable Disease Centre/Tan Tock Seng Hospital during the period from January to February 2008, were included in this retrospective study. Plasma fractions were analyzed using a multiplex-microbead immunoassay. Among the patients, the most common clinical features were fever (100%), arthralgia (90%), rash (50%) - conjunctivitis (40%). Profiles of 30 cytokines, chemokines, - growth factors were able to discriminate the clinical forms of Chikungunya from healthy controls, with patients classified as non-severe - severe disease. Levels of 8 plasma cytokines - 4 growth factors were significantly elevated. Statistical analysis showed that an increase in IL-1beta, IL-6 - a decrease in RANTES were associated with disease severity. This is the first comprehensive report on the production of cytokines, chemokines, - growth factors during acute Chikungunya virus infection. Using these biomarkers, we were able to distinguish between mild disease - more severe forms of Chikungunya fever, thus enabling the identification of patients with poor prognosis - monitoring of the disease.

Imprenta: PloS One, v. 4, n. 1, p. e4261, 2009

Identificador do objeto digital: 10.1371/journal.pone.0004261

Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2009

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