High concentrations of circulating interleukin-6 and monocyte chemotactic protein-1 with low concentrations of interleukin-8 were associated with severe chikungunya fever during the 2009-2010 outbreak in Thailand
Autor(es): Lohachanakul Jindarat, Phuklia Weerawat, Thannagith Montri, Thonsakulprasert Tipparat, Ubol Sukathida
Resumo: The recent outbreak of Chikungunya virus in Thail- caused a rheumatic fever associated with considerable morbidity - fatalities. Thus, it is important to identify biomarker(s) of severe disease induced by this threatening arbovirus. Putative biomarkers in cases of chikungunya fever during an outbreak in the southern part of Thail- in 2009-2010 were identified. Sixty-two patients who had developed fever - myalgia, with or without arthralgia/arthritis, were enrolled - grouped into severe chikungunya fever (CHIKF) (n= 15), mild CHIKF (n= 20) - non-CHIKF (n= 27) to investigate circulating immunological mediators that might serve as markers of severity. Blood samples were taken at presentation (day 1) - 30 days later (day 30) - plasma concentrations of interleukin (IL)-1?, IL-6, IL-8, IL-17, tumor necrosis factor-alpha, monocyte chemotactic protein-1 (MCP-1), matrix metalloproteinase-1, tissue inhibitor of matrix metalloproteinase-1 - viral load were measured by ELISA. On day 1, severe CHIKF - mild CHIKF groups had viral loads of 10(8.5) - 10(8.3) of RNA copies/mL, respectively. At presentation, all CHIKF patients had circulating concentrations of IL-6 - MCP-1 higher than did non-CHIKF patients, whereas amongst the CHKF patients, the severe CHIKF patients had higher IL-6 concentrations than did mild CHIKF patients. Interestingly, severe CHIKF patients had significantly lower concentrations of circulating IL-8 than the other groups of patients, suggesting that high concentrations of IL-6 - MCP-1 with low concentrations of IL-8 may be a determinant of severe chikungunya virus infection.
Imprenta: Microbiology and Immunology, v. 56, n. 2, p. 134-138, 2012
Identificador do objeto digital: 10.1111/j.1348-0421.2011.00417.x
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2012
