Global research priorities for infections that affect the nervous system
Autor(es): John Chandy C, Carabin Hélène, Montano Silvia M, Bangirana Paul, Zunt Joseph R, Peterson Phillip K
Resumo: Infections that cause significant nervous system morbidity globally include viral (for example, HIV, rabies, Japanese encephalitis virus, herpes simplex virus, varicella zoster virus, cytomegalovirus, dengue virus - chikungunya virus), bacterial (for example, tuberculosis, syphilis, bacterial meningitis - sepsis), fungal (for example, cryptococcal meningitis) - parasitic (for example, malaria, neurocysticercosis, neuroschistosomiasis - soil-transmitted helminths) infections. The neurological, cognitive, behavioural or mental health problems caused by the infections probably affect millions of children - adults in low- - middle-income countries. However, precise estimates of morbidity are lacking for most infections, - there is limited information on the pathogenesis of nervous system injury in these infections. Key research priorities for infection-related nervous system morbidity include accurate estimates of disease burden; point-of-care assays for infection diagnosis; improved tools for the assessment of neurological, cognitive - mental health impairment; vaccines - other interventions for preventing infections; improved underst-ing of the pathogenesis of nervous system disease in these infections; more effective methods to treat - prevent nervous system sequelae; operations research to implement known effective interventions; - improved methods of rehabilitation. Research in these areas, accompanied by efforts to implement promising technologies - therapies, could substantially decrease the morbidity - mortality of infections affecting the nervous system in low- - middle-income countries.
Imprenta: Nature, v. 527, n. 7578, p. S178-S186, 2015
Identificador do objeto digital: 10.1038/nature16033
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2015
