Genetic influences on mosquito feeding behavior and the emergence of zoonotic pathogens
Autor(es): Kilpatrick A Marm, Kramer Laura D, Jones Matthew J, Marra Peter P, Daszak Peter, Fonseca Dina M
Resumo: The feeding behavior of vectors influences the likelihood of pathogen invasion - the exposure of humans to vector-borne zoonotic pathogens. We used multilocus microsatellite genetic typing of an introduced mosquito vector - DNA sequencing of mosquito blood meals to determine the impact of hybrid ancestry on feeding behavior - the emergence of West Nile virus (WNV). The probability of ancestry of Culex pipiens mosquitoes from two bionomically divergent forms, form molestus - form pipiens, influenced the probability that they fed on humans but did not explain a late summer feeding shift from birds to humans. We used a simple model to show that the occurrence of pure form molestus mosquitoes would have decreased the likelihood of WNV invasion (R(0) in bird populations) 3- to 8-fold, whereas the occurrence of pure forms pipiens mosquitoes would have halved human exposure compared with the hybrids that are present. Data - modeling suggest that feeding preferences may be influenced by genetic ancestry - contribute to the emergence of vector-borne pathogens transmitted by introduced species, including malaria, - dengue, Chikungunya, yellow fever, - West Nile viruses.
Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 77, n. 4, p. 667-671, 2007
Descritores: Chikungunya virus - DNA ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Genome ; Chikungunya virus - Molecular structure ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Public health
Data de publicação: 2007
