Autor(es): Desdouits Marion, Kamgang Basile, Berthet Nicolas, Tricou Vianney, Ngoagouni Carine, Gessain Antoine, Manuguerra Jean-Claude, Nakouné Emmanuel, Kazanji Mirdad

Resumo: Chikungunya virus (CHIKV) is an alphavirus transmitted by the bite of mosquito vectors. Over the past 10 years, the virus has gained mutations that enhance its transmissibility by the Aedes albopictus vector, resulting in massive outbreaks in the Indian Ocean, Asia - Central Africa. Recent introduction of competent A. albopictus vectors into the Central African Republic (CAR) pose a threat of a Chikungunya fever (CHIKF) epidemic in this region. We undertook this study to assess the genetic diversity - background of CHIKV strains isolated in the CAR between 1975 - 1984 - also to estimate the ability of local strains to adapt to A. albopictus. Our results suggest that, local CHIKV strains have a genetic background compatible with quick adaptation to A. albopictus, as previously observed in other Central African countries. Intense surveillance of the human - vector populations is necessary to prevent or anticipate the emergence of a massive CHIKF epidemic in the CAR.

Palavras-Chave: Central African Republic, Chikungunya virus, Genetic variability

Imprenta: Infection, Genetics and Evolution, v. 33, p. 25-31, 2015

Identificador do objeto digital: 10.1016/j.meegid.2015.04.006

Descritores: Chikungunya virus - DNA ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2015

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