Autor(es): Zheng Kui, Li Ji-ong, Zhang Quanfu, Liang Mifang, Li Chuan, Lin Miao, Huang Jicheng, Li Hua, Xiang Dapeng, Wang Ninlan, Hong Ye, Huang Li, Li Xiaobo, Pan Deguan, Song Wei, Dai Jun, Guo Boxuan, Li Dexin

Resumo: Chikungunya virus (CHIKV) has caused large outbreaks worldwide in recent years, especially on the isl-s of the Indian Ocean - India. The virus is transmitted by mosquitoes (Aedes aegypti), which are widespread in China, with an especially high population density in southern China. Analyses of full-length viral sequences revealed the acquisition of a single adaptive mutation providing a selective advantage for the transmission of CHIKV by this species. No outbreaks due to the local transmission of CHIKV have been reported in China, - no cases of importation were detected on mainl- China before 2008. We followed the spread of imported CHIKV in southern China - analyzed the genetic character of the detected viruses to evaluate their potential for evolution. The importation of CHIKV to mainl- China was first detected in 2008. The genomic sequences of four of the imported viruses were identified, - phylogenetic analysis demonstrated that the sequences were clustered in the Indian Ocean group; however, seven amino acid changes were detected in the nonstructural protein-coding region, - five amino acid changes were noted in the structural protein-coding regions. In particular, a novel substitution in E2 was detected (K252Q), which may impact the neurovirulence of CHIKV. The adaptive mutation A226V in E1 was observed in two imported cases of chikungunya disease. Laboratory-confirmed CHIKV infections among travelers visiting China in 2008 were presented, new mutations in the viral nucleic acids - proteins may represent adaptive mutations for human or mosquito hosts.

Imprenta: Virology Journal, v. 7, p. 8, 2010

Identificador do objeto digital: 10.1186/1743-422X-7-8

Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - DNA ; Chikungunya virus - Neurovirulence ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2010

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