Focus on Chikungunya pathophysiology in human and animal models
Autor(es): Couderc Thérèse, Lecuit Marc
Resumo: Chikungunya virus (CHIKV) is an arbovirus responsible for acute febrile arthralgia. It re-emerged abruptly in 2005 - caused a massive outbreak in the Indian Ocean region, - then extended to Asia. Here we review the pathophysiology of CHIKV infection, based on human - mouse studies, - also present prospects for prevention - therapy of this infection. Our results are discussed in the light of the current knowledge regarding other arthritogenic Alphaviruses.
Palavras-Chave: Chikungunya; Alphavirus; Mouse model; Cell tropism; Fibroblast; Type 1 interferon; Tissue tropism; Central nervous system infection; Vertical transmission; Neonate infection; Ross River virus; Sindbis virus
Imprenta: Microbes and Infection, v. 11, n. 14-15, p. 1197-1205, 2009
Identificador do objeto digital: 10.1016/j.micinf.2009.09.002
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Public health
Data de publicação: 2009
