First evidence of simultaneous circulation of three different Dengue virus serotypes in Africa
Autor(es): Caron Melanie, Grard Gilda, Paupy Christophe, Mombo Illich Mamfred, Bikie Bi Nso Branly, Kassa Kassa Fabrice Roland, Nkoghe Dieudonne, Leroy Eric Maurice
Resumo: Gabon, in Central Africa, was affected for the first time in 2007 - then in 2010 by simultaneous outbreaks of chikungunya - Dengue serotype 2 (DENV-2) viruses. Through the national surveillance of dengue-like syndromes between 2007 - 2010, we observed continuous circulation of DENV-2 in a southward movement. This rapid spread of DENV-2 was associated with the emergence of DENV-1 in 2007 - DENV-3 in 2010. Interestingly, we detected six DENV-2 infected patients with hemorrhagic signs during the second outbreak in 2010. Although these cases do not meet all st-ard WHO criteria for severe Dengue with hemorrhage (formerly DHF), this is the first report of several dengue fever cases associated with hemorrhagic signs during a simultaneous circulation of different DENV serotypes in Africa. Together, these findings suggest that DENV is becoming more widely established on this continent - that DHF will likely become a serious public-health problem in the near future.
Imprenta: PloS One, v. 8, n. 10, p. e78030, 2013
Identificador do objeto digital: 10.1371/journal.pone.0078030
Descritores: Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya virus - Real Time PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2013
