Factors shaping the adaptive landscape for arboviruses: Implications for the emergence of disease
Autor(es): Coffey Lark L, Forrester Naomi, Tsetsarkin Konstantin, Vasilakis Nikos, Weaver Scott C
Resumo: Many examples of the emergence or re-emergence of infectious diseases involve the adaptation of zoonotic viruses to new amplification hosts or to humans themselves. These include several instances of simple mutational adaptations, often to hosts closely related to the natural reservoirs. However, based on theoretical grounds, arthropod-borne viruses, or arboviruses, may face several challenges for adaptation to new hosts. Here, we review recent findings regarding adaptive evolution of arboviruses - its impact on disease emergence. We focus on the zoonotic alphaviruses Venezuelan equine encephalitis - chikungunya viruses, which have undergone adaptive evolution that mediated recent outbreaks of disease, as well as the flaviviruses dengue - West Nile viruses, which have emerged via less dramatic adaptive mechanisms.
Palavras-Chave: Adaptation; Alphavirus; Emergence; Evolution; Fitness; Flavivirus; Mosquito; Vector
Imprenta: Future Microbiology, v. 8, n. 2, p. 155-176, 2013
Identificador do objeto digital: 10.2217/fmb.12.139
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue
Data de publicação: 2013
