Autor(es)Larrieu Sophie, Pouderoux Nicolas, Pistone Thierry, Filleul Laurent, Receveur Marie-Catherine, Sissoko Daouda, Ezzedine Khaled, Malvy Denis

ResumoIn 2005-2006, a major epidemic of CHIKV infection occurred in the Isl-s of the south-western Indian Ocean, - longst-ing manifestations seemed to be more frequent than described before. To describe the frequency - related factors of late clinical manifestations of CHIKV infection among imported cases living in Aquitaine area, France. All patients recruited through the travel clinic - tropical medicine unit of the University Hospital Centre of Bordeaux with possible CHIKV infection were prospectively recorded, - confirmed cases of CHIKV infection were interviewed 2 years after infection. Factors associated with the persistence of symptoms were determined by multivariate logistic regression. Among the 29 cases followed, 17 still suffered from arthralgia 2 years after infection, - most of them had never recovered from the initial phase of the condition. The risk of persistent arthralgia tended to be higher among subjects with low educational level, subjects infected in the Reunion Isl-, - when initial phase lasted 30 days or more - was characterised by a severe pain. Consistent with previous studies, our findings showed worsened late manifestations among patients returning from Indian Ocean area. Persistence of symptoms tended to be linked with clinical burden during the acute phase, which can be informative for early recognition - management of patients at risk for developing persistent rheumatic symptoms. Cryoglobulins failed to be identified in seronegative patients with invalidating dengue-like syndrome.

Palavras-ChaveChikungunya; Chronic; Arthralgia; Travellers; Cryoglobulins

ImprentaJournal of Clinical Virology, v. 47, n. 1, p. 85-88, 2010

DescritoresChikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de Publicação:2010