Epidemiology, clinical manifestations, and diagnosis of Chikungunya fever: Lessons learned from the re-emerging epidemic
Autor(es): Mohan Alladi, Kiran D H N, Manohar I Chiranjeevi, Kumar D Prabath
Resumo: Chikungunya fever, caused by Chikungunya virus," is an arbovirus disease transmitted by the bite of infected mosquitoes belonging to the genus Aedes. Chikungunya fever epidemics have been reported from several countries around the world. The disease that was silent for nearly 32 years re-emerged in the October 2005 outbreak in India that is still ongoing. The incubation period ranges from 3 to 12 days. The onset is usually abrupt - the acute stage is characterized by sudden onset with high-grade fever, severe arthralgias, myalgias, - skin rash. Swollen tender joints - crippling arthritis are usually evident. In the chronic stage, relapses that include sensation of fever, asthenia, exacerbation of arthralgias, inflammatory polyarthritis, - stiffness may be evident. Neurological, ocular, - mucocutaneous manifestations have also been described. Chronic arthritis may develop in about 15% of the patients. Viral culture is the gold st-ard for the diagnosis of Chikungunya fever. Reverse transcription polymerase chain reaction - real-time loop-mediated isothermal amplification have also been found to be useful. Serodiagnostic methods for the detection of immunoglobulin M - immunoglobulin G antibodies against Chikungunya virus are more frequently used. Chikungunya is a self-limiting disease; however, severe manifestations such as meningoencephalitis, fulminant hepatitis, - bleeding manifestations may sometimes be life-threatening. Treatment is symptomatic - supportive. Prevention by educating the community - public health officials, vector control measures appear to be the best approach at controlling Chikungunya fever as no commercially available vaccine is available for public use in India for this condition presently."
Palavras-Chave: Chikungunya; Diagnosis; Epidemiology; Treatment
Imprenta: Indian Journal of Dermatology, v. 55, n. 1, p. 54-63, 2010
Identificador do objeto digital: 10.4103/0019-5154.60355
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Antibodies ; Chikungunya virus - Real Time PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2010
