Emerging viral infections in rheumatic diseases
Autor(es): Khasnis Atul A, Schoen Robert T, Calabrese Leonard H
Resumo: To review the current literature regarding emerging viral pathogens in the context of rheumatic diseases with the intent of increasing awareness among rheumatologists - treating physicians, aiming at early recognition - treatment of these patients. We reviewed case reports, case series, review articles, - original reports from PubMed (www.pubmed.gov) regarding various aspects influencing spread of infectious diseases including epidemiology - viral - human factors that are potentially responsible for the emergence of new viral pathogens. By consensus, we generated a list of emerging viral pathogens pertinent regarding presentation with rheumatologic manifestations - then short-listed several with particular clinical relevance including hepatitis B, human immunodeficiency virus, - Chikungunya viruses for discussion in greater detail. There has been a change in the epidemiology - clinical rheumatic manifestations of previously known viral pathogens as well as the emergence of new viral pathogens as a consequence of factors such as changes in environmental temperature - its consequences, changes in vector - parasite biology, - human influences such as treatment - immunization. Rheumatologists need to be cognizant of the changing l-scape of emerging viral pathogens as they may present with myriad clinical features. Recognition of these pathogens is important to guide correct treatment - prognosis. Given the current scenario of global epidemiologic factors that influence viral emergence, we should expect a growing number of future emerging pathogens. Ongoing research directed at underst-ing pathogenesis - transmission as well as developing better preventive strategies may help counter the threat posed by emerging pathogens.
Palavras-Chave: Emerging viral infections; Epidemiology; Alphavirus; Chikungunya; Rheumatic diseases
Imprenta: Seminars in Arthritis and Rheumatism, v. 41, n. 2, p. 236-246, 2011
Identificador do objeto digital: 10.1016/j.semarthrit.2011.01.008
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Epidemiology
Data de publicação: 2011
