Emergence of chikungunya seropositivity in healthy Malaysian adults residing in outbreak-free locations: Chikungunya seroprevalence results from the Malaysian Cohort
Autor(es)Azami Nor Azila Muhammad, Salleh Sharifah Azura, Shah Shamsul Azhar, Neoh Hui-min, Othman Zulhabri, Zakaria Syed Zulkifli Syed, Jamal Rahman
ResumoIn 1998, Malaysia experienced its first chikungunya virus (CHIKV) outbreak in the suburban areas followed by another two in 2006 (rural areas) - 2008 (urban areas), respectively. Nevertheless, there is still a lack of documented data regarding the magnitude of CHIKV exposure in the Malaysian population. The aim of this study was to determine the extent of chikungunya virus infection in healthy Malaysian adults residing in outbreak-free locations. A cross sectional study of chikungunya (CHIK) seroprevalence was carried out in 2009 amongst The Malaysian Cohort participants living in four states (Kuala Lumpur, Selangor, Pahang - Negeri Sembilan). A total of 945 participants were r-omly identified for the study. Potential risk factors for CHIK infection were determined via questionnaires, - IgG antibodies against CHIK were detected by an enzyme-linked immunosorbent assay. Logistic regression identified risk factors associated with CHIK seropositivity, while geographical information system was used for visual - spatial analysis. From the 945 serum samples tested, 5.9% was positive for CHIK IgG. Being male, Malay, rural occupancy - Negeri Sembilan residency were identified as univariate predictors for CHIK seropositivity, while multivariate analysis identified being male - rural occupancy as risk factors. This study provided evidence that CHIK is slowly emerging in Malaysia. Although the current baseline seroprevalence is low in this country, increasing number of CHIK cases reported to the Malaysia Ministry of Health imply the possibility of CHIK virus becoming endemic in Malaysia.
Palavras-ChaveAdult; Malaysia/Epidemiology; Chikungunya virus; Seroprevalence study; Rural
ImprentaBMC Infectious Diseases, v. 13, p. 67, 2013
Identificador do Objeto Digital10.1186/1471-2334-13-67
DescritoresChikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya virus - Molecular methods ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de Publicação:2013
