Autor(es): Nunes Marcio Roberto Teixeira, Faria Nuno Rodrigues, de Vasconcelos Janaina Mota, Golding Nick, Kraemer Moritz U G, de Oliveira Layanna Freitas, Azevedo Raimunda do Socorro da Silva, da Silva Daisy Elaine Andrade, da Silva Eliana Vieira Pinto, da Silva Sandro Patroca, Carvalho Valéria Lima, Coelho Giovanini Evelim, Cruz Ana Cecília Ribeiro, Rodrigues Sueli Guerreiro, Vianez Joao Lídio da Silva Gonçalves, Nunes Bruno Tardelli Diniz, Cardoso Jedson Ferreira, Tesh Robert B, Hay Simon I, Pybus Oliver G, Vasconcelos Pedro Fernando da Costa

Resumo: In December 2013, an outbreak of Chikungunya virus (CHIKV) caused by the Asian genotype was notified in the Caribbean. The outbreak has since spread to 38 regions in the Americas. By September 2014, the first autochthonous CHIKV infections were confirmed in Oiapoque, North Brazil, - in Feira de Santana, Northeast Brazil. We compiled epidemiological - clinical data on suspected CHIKV cases in Brazil - polymerase-chain-reaction-based diagnostic was conducted on 68 serum samples from patients with symptom onset between April - September 2014. Two imported - four autochthonous cases were selected for virus propagation, RNA isolation, full-length genome sequencing, - phylogenetic analysis. We then followed CDC/PAHO guidelines to estimate the risk of establishment of CHIKV in Brazilian municipalities. We detected 41 CHIKV importations - 27 autochthonous cases in Brazil. Epidemiological - phylogenetic analyses indicated local transmission of the Asian CHIKV genotype in Oiapoque. Unexpectedly, we also discovered that the ECSA genotype is circulating in Feira de Santana. The presumed index case of the ECSA genotype was an individual who had recently returned from Angola - developed symptoms in Feira de Santana. We estimate that, if CHIKV becomes established in Brazil, transmission could occur in 94% of municipalities in the country - provide maps of the risk of importation of each strain of CHIKV in Brazil. The etiological strains associated with the early-phase CHIKV outbreaks in Brazil belong to the Asian - ECSA genotypes. Continued surveillance - vector mitigation strategies are needed to reduce the future public health impact of CHIKV in the Americas.

Palavras-Chave: Chikungunya virus; National surveillance; Public health; Spatial prediction; Statistical methods

Imprenta: BMC Medicine, v. 13, p. 102, 2015

Identificador do objeto digital: 10.1186/s12916-015-0348-x

Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Genome ; Chikungunya virus - Pathogenesis ; Chikungunya virus - RNA ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2015

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