East Central South African genotype as the causative agent in reemergence of Chikungunya outbreak in India
Autor(es): Dash P K, Parida M M, Santhosh S R, Verma S K, Tripathi N K, Ambuj S, Saxena P, Gupta N, Chaudhary M, Babu J Pradeep, Lakshmi V, Mamidi N, Subhalaxmi M V S, Lakshmana Rao P V, Sekhar K
Resumo: Chikungunya fever is an important arboviral infection prevalent throughout Africa - Southeast Asia. Recently, in 2006, it has reemerged in many parts of India, affecting more than a million persons. A detail serological, virological, - molecular investigation of this unprecedented outbreak was carried out by collecting - studying 540 samples from all the affected regions of India during this epidemic. An in-depth investigation revealed the presence of anti-Chikungunya antibodies in 68% of the samples - genomic RNA in 49% of them. In addition 32 Chikungunya viruses were isolated from 45 representative polymerase chain reaction-positive samples. The nucleotide sequences of partial E1 gene of 25 representative Chikungunya viruses were deciphered. The sequence analysis indicated that all the isolates of this epidemic belonged to the new Indian Ocean isl- clade of East Central South (ECS) African genotype. This study conclusively proved the genotype shift from Asian to ECS African as the major factor in the reemergence of Chikungunya in an unprecedented outbreak in India after a gap of 32 years.
Imprenta: Vector Borne and Zoonotic Diseases, v. 7, n. 4, p. 519-527, 2007
Identificador do objeto digital: 10.1089/vbz.2007.7272
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya virus - RT-PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2007
