Early events in Chikungunya virus infection-from virus cellbinding to membrane fusion
Autor(es): van Duijl-Richter Mareike K S, Hoornweg Tabitha E, Rodenhuis-Zybert Izabela A, Smit Jolanda M
Resumo: Chikungunya virus (CHIKV) is a rapidly emerging mosquito-borne alphavirus causing millions of infections in the tropical - subtropical regions of the world. CHIKV infection often leads to an acute self-limited febrile illness with debilitating myalgia - arthralgia. A potential long-term complication of CHIKV infection is severe joint pain, which can last for months to years. There are no vaccines or specific therapeutics available to prevent or treat infection. This review describes the critical steps in CHIKV cell entry. We summarize the latest studies on the virus-cell tropism, virus-receptor binding, internalization, membrane fusion - review the molecules - compounds that have been described to interfere with virus cell entry. The aim of the review is to give the reader a state-of-the-art overview on CHIKV cell entry - to provide an outlook on potential new avenues in CHIKV research.
Palavras-Chave: Chikungunya virus; Alphavirus; Cell tropism; Clathrin; Endocytosis; Entry; Entry inhibitors; Fusion; Neutralizing antibodies; Receptor
Imprenta: Viruses, v. 7, n. 7, p. 3647-3674, 2015
Identificador do objeto digital: 10.3390/v7072792
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Antibodies ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine
Data de publicação: 2015
