Autor(es)Kam Yiu-Wing, Simarmata Diane, Chow Angela, Her Zhisheng, Teng Terk-Shin, Ong Edward K S, Rénia Laurent, Leo Yee-Sin, Ng Lisa F P

ResumoChikungunya virus (CHIKV) - related arboviruses have been responsible for large epidemic outbreaks with serious economic - social impact. Although infected individuals clear the virus from the blood, some develop debilitating - prolonged arthralgia. We investigated specificity - strength of antibody responses in a longitudinal study on CHIKV-infected patients - analyzed their association with viral load, cytokine profile, - severity. We found that CHIKV-specific response is dominated by immunoglobulin G3 (IgG3) antibodies. The antibodies were neutralizing, - patients with high viremia rapidly developed high levels of anti-CHIKV antibodies of this specific isotype. Although these patients endured a more severe disease progression during the acute viremic phase, they cleared the virus faster - did not experience persistent arthralgia. However, significant persistent arthralgia was observed in patients with low viremia who developed IgG3 at a later stage. Absence of early CHIKV-specific IgG3 may therefore serve as a specific marker of patients with increased risk of disease.

ImprentaThe Journal of Infectious Diseases, v. 205, n. 7, p. 1147-1154

DescritoresChikungunya virus - Arbovirus ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de Publicação:2012