Autor(es): Ofodile Okom Nkili F C

Resumo: Disifin has emerged as a unique - very effective agent used in disinfection of wounds, disinfection of surfaces, materials - water, - other substances contaminated with almost every type of pathogenic microorganism ranging from viruses, bacteria, fungi - yeast, -, very possibly, protozoan parasites, as well. The major active component of Disifin is tosylchloramide sodium (chloramine T). However, the mechanism by which Disifin suppresses the activities of pathogenic microbial agents remains enigmatic. The molecular mechanisms, - the receptors - the signal transducing pathways responsible for the biological effects of Disifin are largely unknown. Despite considerable advances, enormous investigative efforts - large resources invested in the research on infectious diseases, microbial infection still remains a public health problem in many parts of the world. The exact nature of the pathogenic agents responsible for many infectious diseases, - the nature of the receptors mediating the associated inflammatory events are incompletely understood. Recent advances in underst-ing the molecular basis for mammalian host immune responses to microbial invasion suggest that the first line of defense against microbes is the recognition of pathogen-associated molecular patterns (PAMPs) by a family of transmembrane pattern-recognizing - signal transducing receptor proteins called Toll-like receptors (TLRs). The TLR family plays an instructive role in innate immune responses against microbial pathogens, as well as the subsequent induction of adaptive immune responses. TLRs mediate recognition - inflammatory responses to a wide range of microbial products - are crucial for effective host defense by eradication of the invading pathogens. Now, recent updates demonstrated the ability of Disifin-derived products, Disifin-Animal - Disifin-Pressant to effectively suppress the progression - activities of Chikungunya fever - that of avian influenza A virus [A/cardialis/Germany/72, H7N1: the agent of a highly pathogenic avian influenza (HPAI)] infection, respectively. Overall, the above findings led me to suggest that Disifin - TLRs may mechanistically overlap in the processes of executing their functions against pathogenic microbial organisms. Thus, elucidating - better underst-ing of the molecular underpinnings responsible for the biochemical effects of Disifin-products, - the nature - mode of the interaction(s) of Disifin with TLRs in the process of exerting their biological effects may open a novel dimension in the research of infectious diseases, which may provide novel therapeutic targets for the prevention - treatment of a wide range of infectious diseases.

Palavras-Chave: Disifin-(Sodium tosylchloramide); Toll-like receptor (TLRs); Pathogenic microbial organisms; Signal transducing pathway; Exploiting the roles of the Toll-like receptors

Imprenta: Journal of Industrial Microbiology & Biotechnology, v. 34, n. 12, p. 751-762, 2007

Identificador do objeto digital: 10.1007/s10295-007-0252-2

Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2007

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