Autor(es): Zaid Ali, Rulli Nestor E, Rolph Michael S, Suhrbier Andreas, Mahalingam Suresh

Resumo: Mosquito-borne alphaviruses such as chikungunya virus, o'nyong-nyong virus, - Ross River virus (RRV) cause sporadic, sometimes large, outbreaks of rheumatic disease worldwide. This study was designed to test the effect of treating RRV-induced arthritis using the anti-tumor necrosis factor (anti-TNF) drug etanercept in a mouse model of rheumatic disease. Mice were infected with RRV - treated with etanercept. Weight gain was measured, tissue viral titers were determined, - histologic changes in muscle - joint tissues were assessed. RRV-infected mice treated with etanercept showed decreased weight gain, higher viral titers in muscle, joints, - blood, - more tissue damage - inflammatory cell recruitment than RRV-infected mice without treatment. Anti-TNF therapy is unlikely to be useful in treating alphaviral arthritides. During alphaviral epidemics, careful monitoring of patients being treated with anti-TNF agents may be warranted.

Imprenta: Arthritis and Rheumatism, v. 63, n. 2, p. 488-491, 2011

Identificador do objeto digital: 10.1002/art.30112

Descritores: Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology

Data de publicação: 2011

INDICADORES

ACESSO