Autor(es): Laoprasopwattana Kamolwish, Kaewjungwad Lamy, Jarumanokul Roongrueng, Geater Alan

Resumo: Clinical manifestations of chikungunya (CHIK) are similar to those of dengue. It would be useful to be able to identify clinical manifestations that could reliably help to differentiate CHIK from dengue - other acute febrile illnesses during a CHIK outbreak in a dengue-endemic area. A prospective cohort study was conducted between April - July 2009 in children aged 1 month to 15 years who lived in a CHIK outbreak area in southern Thail- - who had fever <7 days with arthralgia/arthritis, myalgia or rash. CHIK was confirmed by real-time polymerase chain reaction or the indirect immunofluorescence test. Fifty patients were suspected of having CHIK, of whom 32 were confirmed, 1 had coinfection with dengue viral infection (DVI), 10 had dengue alone - 7 had an acute febrile illness. The specificity - positive predictive value of fever - arthralgia together to diagnose CHIK were 47.1% - 74.2%, - the corresponding values of the st-ard clinical triad (fever, arthralgia, rash) were 70.6% - 83.3%, respectively. Fever ? 2 days, skin rash during fever - white blood cell count ? 5000 cells/mm(3) were independently - significantly associated with CHIK in comparison with DVI - acute febrile illnesses, with relative risk ratios (95% confidence intervals) of 10.4 (0.9-116) - 13.7 (1.3-145), 13.8 (1.2-164) - 14.8 (1.6-168), - 18.3 (1.7-194) - 1.8 (0.1-20.6), respectively. During a CHIK outbreak in a DVI-endemic area, overdiagnosis of CHIK was common. Skin rash during fever - white blood cell count ? 5000 cells/mm(3) or specific antigen testing (if available) can be helpful in differentiating CHIK from DVI.

Imprenta: The Pediatric Infectious Disease Journal, v. 31, n. 5, p. 459-463, 2012

Identificador do objeto digital: 10.1097/INF.0b013e31824bb06d

Descritores: Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya virus - Real Time PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2012

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