Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
Autor(es): Malvy Denis, Ezzedine Khaled, Mamani-Matsuda Maria, Autran Brigitte, Tolou Hugues, Receveur Marie-Catherine, Pistone Thierry, Rambert Jérome, Moynet Daniel, Mossalayi Djavad
Resumo: Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood. We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators - persistence of specific IgM antibodies over 24 months following infection. Underst-ing the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.
Imprenta: BMC Infectious Diseases, v. 9, p. 200, 2009
Identificador do objeto digital: 10.1186/1471-2334-9-200
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology
Data de publicação: 2009
