Autor(es): Halstead Scott B, Cohen Sanford N

Resumo: During the decade of the 1960s, the epidemiology of a new dengue disease, dengue hemorrhagic fever - dengue shock syndrome (DHF/DSS), was described by collaborative research performed by Thai scientists from many institutions - by workers at the U.S. Army's SEATO Medical Research Laboratory in Bangkok, Thail-. Careful clinical - physiological studies provided the initial description of DSS. DSS cases were caused by each of the four dengue viruses (DENV) - not chikungunya (CHIK) virus or DENV 5 - 6, were associated with a secondary-type dengue antibody response in children over the age of 1 year, were associated with a primary antibody response in infants less than 1 year old whose mothers had neutralizing antibodies to all four DENV, were associated more frequently with secondary DENV 2 infections than those due to DENV 1 - 3, - were more common in females than males over the age of 3 years. Robust laboratory methods for growth - recovery of DENV in tissue cultures were introduced. In addition, life-saving principles of fluid - plasma protein resuscitation of hypovolemia were described. Most epidemiological observations made during the decade of the 1960s have been confirmed in the succeeding 45 years. Much contemporary research on pathogenesis fails to address the two distinct immunological antecedents of DHF/DSS.

Imprenta: Microbiology and Molecular Biology Reviews, v. 79, n. 3, p. 281-291, 2015

Identificador do objeto digital: 10.1128/MMBR.00009-15

Descritores: Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2015

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