Dengue and chikungunya seroprevalence in Gabonese infants prior to major outbreaks in 2007 and 2010: A sero-epidemiological study
Autor(es): Gabor Julian Justin, Schwarz Norbert Georg, Esen Meral, Kremsner Peter Gottfried, Grobusch Martin Peter
Resumo: Apart from outbreak reports, little is known about the endemicity of dengue - chikungunya virus in African countries. We investigated serum samples collected in Gabon before major outbreaks in 2007 - 2010 in order to identify pre-outbreak-circulation of both viruses. Serum samples from Gabonese infants (162) were analyzed at 3, 9, 15 - 30 months of age by commercial ELISA for dengue - chikungunya IgG-antibodies. If samples were positive medical records of participants were analyzed for symptoms concordant with dengue - chikungunya infections during the time period of assumed seroconversion. IgG-antibodies against dengue were found in 12.3%, - IgG-antibodies against chikungunya in 0.6% of infants tested. Using the four measuring time points, we estimated corresponding incidences of 51/1.000 person-years - 2.5/1.000 person-years, respectively. Symptoms in positive-tested infants were mostly non-specific. Seropositivity suggests that both viruses circulated before the well-noticed outbreaks. Clinical diagnosis of dengue - chikungunya is difficult especially in infants, underscoring the need for accurate - reliable diagnostic tests as well as awareness of medical personnel. NCT00167843.
Palavras-Chave: Chikungunya; Dengue; ELISA; Infants; Seroprevalence
Imprenta: Travel Medicine and Infectious Disease, v. 14, n. 1, p. 26-31, 2016
Identificador do objeto digital: 10.1016/j.tmaid.2016.01.005
Descritores: Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue
Data de publicação: 2016
