Autor(es): Chen Lin H, Wilson Mary E

Resumo: Dengue virus (DENV) - chikungunya virus (CHIKV) cause significant morbidity in many world regions - their epidemiology, pathogenesis, vector issues, - control - prevention continue to fascinate researchers. This review focuses on the progress in these areas in the past 2 years. Recent studies have highlighted the features of the epidemiology of DENV - CHIKV in Africa, some places of transmission being detected through travelers as sentinels. Autochthonous transmission of both viruses has been documented in France, raising concern regarding the potential for outbreaks where a competent vector, Aedes albopictus, is present. Some aspects of immune response following DENV - CHIKV infections have been elucidated. New diagnostic techniques for DENV have been explored as well as treatment for CHIKV. Research on Wolbachia as a means of biologic control of mosquito-borne infections including DENV - CHIKV has made significant progress. These studies further our underst-ing of the evolving DENV - CHIKV epidemiology - potential transmission in nonendemic regions, - can contribute to the assessment of travelers. The new information on immunological responses to these viruses influences the vaccine development. Risk factors for severe disease - new therapeutic options could improve current treatment. Finally, research on Wolbachia holds promise in these two important vector-borne viral infections.

Palavras-Chave: Aedes; Chikungunya; Dengue; Flavivirus; Mosquito-borne infections; Travelers; Wolbachia

Imprenta: Current Opinion in Infectious Diseases, v. 25, n. 5, p. 523-529, 2012

Identificador do objeto digital: 10.1097/QCO.0b013e328356ffd5

Descritores: Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Immune response ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2012

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