Autor(es)Rana Jyoti, Sreejith R, Gulati Sahil, Bharti Isha, Jain Surangna, Gupta Sanjay

ResumoSuccessful infection with chikungunya virus (CHIKV) depends largely on the ability of this virus to manipulate cellular processes in its favour through specific interactions with several host factors. The knowledge of virus-host interactions is of particular value for underst-ing the interface through which therapeutic strategies could be applied. In the current study, the authors have employed a computational method to study the protein interactions between CHIKV - both its human host - its mosquito vector. In this structure-based study, 2028 human - 86 mosquito proteins were predicted to interact with those of CHIKV through 3918 - 112 unique interactions, respectively. This approach could predict 40 % of the experimentally confirmed CHIKV-host interactions along with several novel interactions, suggesting the involvement of CHIKV in intracellular cell signaling, programmed cell death, - transcriptional - translational regulation. The data corresponded to those obtained in earlier studies for HIV - dengue viruses using the same methodology. This study provides a conservative set of potential interactions that can be employed for future experimental studies with a view to underst-ing CHIKV biology.

ImprentaArchives of Virology, v. 158, n. 6, p. 1159-1172, 2013

DescritoresChikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Protein synthesis ; Chikungunya virus - Proteins ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue

Data de Publicação:2013