Dealing with low pH: Entry and exit of alphaviruses and flaviviruses
Autor(es): Sánchez-San Martín Claudia, Liu Catherine Y, Kielian Margaret
Resumo: The alphaviruses - flaviviruses include many important human pathogens, such as the dengue, West Nile, - Chikungunya viruses. These enveloped viruses infect cells by a membrane fusion reaction triggered by the low pH in endosomes. Fusion is mediated by viral membrane proteins through their acid-dependent conversion from a dimer on the virus surface to a homotrimer inserted into the host cell membrane. Here we review recent studies on the regulatory mechanisms that silence these fusion proteins during virus exit - that sense low pH - mediate protein refolding during virus entry. We discuss results using truncated proteins to dissect the fusion reaction, - future research directions including the development of antiviral therapies against these medically important viruses.
Imprenta: Trends in Microbiology, v. 17, n. 11, p. 514-521, 2009
Identificador do objeto digital: 10.1016/j.tim.2009.08.002
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue
Data de publicação: 2009
