Autor(es): Chirathaworn Chintana, Poovorawan Yong, Lertmaharit Somrat, Wuttirattanakowit Norra

Resumo: To investigate cytokine profile in patients with chikungunya virus (CHIKV) infection. Twenty eight pairs of serum samples collected from CHIKV infected patients during the outbreak of chikungunya fever in South Thail- in 2008 were obtained. A multiple cytokine assay for detection of 17 cytokines was performed. In the acute stage of CHIKV infection, the patients had significantly higher levels of interleukin-6, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 - tumor necrosis factor alpha than the control (P<0.001, P=0.023, P=0.015, P<0.001 - P=0.024, respectively). When the disease developed to the recovery stage, the patients had significantly lower levels of interleukin-6, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 - macrophage inflammatory protein beta than in the acute stage (P<0.001). This study provides additional information that these cytokines could play roles in pathogenesis of CHIKV infection - could be used as disease biomarkers or drug targets.

Palavras-Chave: Chikungunya virus; CytokineInterleukin-6; Granulocyte-macrophage colony-stimulating factor; Monocyte chemotactic protein 1

Imprenta: Asian Pacific Journal of Tropical Medicine, v. 6, n. 8, p. 631-634, 2013

Identificador do objeto digital: 10.1016/S1995-7645(13)60108-X

Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2013

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