Cutaneous manifestations of chikungunya during a recent epidemic in Calicut, north Kerala, south India
Autor(es): Riyaz Najeeba, Riyaz A, Abdul Latheef E N, Anitha P M, Aravindan K P, Nair Anupama S, Shameera P
Resumo: There was a recent epidemic of chikungunya (CKG) in Calicut - other northern districts of Kerala, South India, affecting thous-s of people. To study the cutaneous manifestations of CKG - to have a serological - histopathological correlation. A total of 162 patients (63 males - 99 females) with cutaneous manifestations of CKG were enrolled in the study - serological confirmation was done with capture IgM ELISA for CKG. Skin biopsy was done in all representative cases. Cutaneous manifestations were found more in females. There were 23 children, the youngest being 39 days old. Generalized erythematous macular rash was the most common finding. Vesicles - bullae were also common especially in infants. Localized erythema of the nose - pinnae, erythema - swelling of the pre existing scars - striae - toxic epidermal necrolysis-like lesions sparing mucosae were the other interesting findings. Different types of pigmentation were observed with a striking nose pigmentation in a large number of patients, by looking at which even a retrospective diagnosis of CKG could be made. Hence we suggest this peculiar pigmentation may be called chik sign". There was flare up of existing dermatoses like psoriasis, lichen planus - unmasking of Hansen's disease with type 1 reaction. Serological tests were positive in 97%. Some hitherto unreported histopathologic findings like melanophages in the erythematous rashes were observed. A spectrum of cutaneous manifestations of CKG with a wide variety of unusual presentations with confirmed serological - histopathological evidence was encountered."
Palavras-Chave: Chikungunya; Cutaneous manifestations; "Chik sign"; IgM capture ELISA; Histopathology
Imprenta: Indian Journal of Dermatology, Venereology and Leprology, v. 76, n. 6, p. 671-676, 2010
Identificador do objeto digital: 10.4103/0378-6323.72466
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya virus - Serological diagnosis ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2010
