Autor(es): von Rhein Christine, Weidner Tatjana, Henß Lisa, Martin Judith, Weber Christopher, Sliva Katja, Schnierle Barbara S

Resumo: Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes chikungunya fever - has infected millions of people mainly in developing countries. The associated disease is characterized by rash, high fever, - severe arthritis that can persist for years. CHIKV has adapted to Aedes albopictus, which also inhabits temperate regions including Europe - the United States of America. CHIKV has recently caused large outbreaks in Latin America. No treatment or licensed CHIKV vaccine exists. Traditional medicines are known to have anti-viral effects; therefore, we examined whether curcumin or Boswellia serrata gum resin extract have antiviral activity against CHIKV. Both compounds blocked entry of CHIKV Env-pseudotyped lentiviral vectors - inhibited CHIKV infection in vitro. In addition, vesicular stomatitis virus vector particles - viral infections were also inhibited to the same extent, indicating a broad antiviral activity. Although the bioavailability of these compounds is rather poor, they might be used as a lead structure to develop more effective antiviral drugs or might be used topically to prevent CHIKV spread in the skin after mosquito bites.

Palavras-Chave: Boswellic acid; Chikungunya virus; Curcumin; Traditional medicine; Vesicular stomatitis virus

Imprenta: Antiviral Research, v. 125, p. 51-57, 2016

Identificador do objeto digital: 10.1016/j.antiviral.2015.11.007

Descritores: Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever

Data de publicação: 2016

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