Autor(es): Mahauad-Fernandez Wadie D, Jones Philip H, Okeoma Chioma M

Resumo: Bone marrow stromal antigen 2 (BST-2; also known as tetherin or CD317) is an IFN-inducible gene that functions to block the release of a range of nascent enveloped virions from infected host cells. However, the role of BST-2 in viral pathogenesis remains poorly understood. BST-2 plays a multifaceted role in innate immunity, as it hinders retroviral infection - possibly promotes infection with some rhabdo- - orthomyxoviruses. This paradoxical role has probably hindered exploration of BST-2 antiviral function in vivo. We reported previously that BST-2 tethers Chikungunya virus (CHIKV)-like particles on the cell plasma membrane. To explore the role of BST-2 in CHIKV replication - host protection, we utilized CHIKV strain 181/25 to examine early events during CHIKV infection in a BST-2(-/-) mouse model. We observed an interesting dichotomy between WT - BST-2(-/-) mice. BST-2 deficiency increased inoculation site viral load, culminating in higher systemic viraemia - increased lymphoid tissues tropism. A suppressed inflammatory innate response demonstrated by impaired expression of IFN-?, IFN-? - CD40 lig- was observed in BST-2(-/-) mice compared with the WT controls. These findings suggested that, in part, BST-2 protects lymphoid tissues from CHIKV infection - regulates CHIKV-induced inflammatory response by the host.

Imprenta: The Journal of General Virology, v. 95, Pt 11, p. 2450-2461, 2014

Identificador do Objeto Digital: 10.1099/vir.0.068643-0

Descritores: Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology

Data de Publicação: 2014