Control of immunopathology during chikungunya virus infection
Autor(es): Petitdemange Caroline, Wauquier Nadia, Vieillard Vincent
Resumo: After several decades of epidemiologic silence, chikungunya virus (CHIKV) has recently re-emerged, causing explosive outbreaks - reaching the 5 continents. Transmitted through the bite of Aedes species mosquitoes, CHIKV is responsible for an acute febrile illness accompanied by several characteristic symptoms, including cutaneous rash, myalgia, - arthralgia, with the latter sometimes persisting for months or years. Although CHIKV has previously been known as a relatively benign disease, more recent epidemic events have brought waves of increased morbidity - fatality, leading it to become a serious public health problem. The host's immune response plays a crucial role in controlling the infection, but it might also contribute to the promotion of viral spread - immunopathology. This review focuses on the immune responses to CHIKV in human subjects with an emphasis on early antiviral immune responses. We assess recent developments in the underst-ing of their possible Janus-faced effects in the control of viral infection - pathogenesis. Although preventive vaccination - specific therapies are yet to be developed, exploring this interesting model of virus-host interactions might have a strong effect on the design of novel therapeutic options to minimize immunopathology without impairing beneficial host defenses.
Palavras-Chave: Chikungunya virus; Immune responses; Immunotherapy; Vaccination
Imprenta: The Journal of Allergy and Clinical Immunology, v. 135, n. 4, p. 846-855, 2015
Identificador do objeto digital: 10.1016/j.jaci.2015.01.039
Descritores: Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Immune response ; Chikungunya virus - Immunopathology ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2015
