Autor(es): Kularatne S A M, Gihan M C, Weerasinghe S C, Gunasena S

Resumo: To compare the clinical - laboratory features of confirmed cases of Chikungunya - Dengue fever; to validate the clinical diagnosis based on serology. Cases with a clinical diagnosis of Chikungunya - Dengue fever were recruited for seroconfirmation during a concurrent epidemic in 2006-07, at the General Hospital, Peradeniya, Sri Lanka. Of 54 patients with fever, serology confirmed 21 with Chikungunya infection, 20 with Dengue infection, - three co-infections, with sensitivity of the clinical diagnosis of 92% for Chikungunya fever - 95% for Dengue fever. The mean age of patients with Chikungunya fever was 45 years (range 21-74 years), - patients with Dengue fever was 30 years (range 15-63 years) (p = 0.005). Sixteen (70%) of Chikungunya fever patients were females, while 15 (71%) of those with Dengue fever were males (p = 0.007). Arthralgia was common to both groups (p = 0.155), while headache - a bleeding tendency were observed more in patients with Dengue fever. Twelve (57%) Chikungunya cases had acute arthritis compared with none in the Dengue group (p = 0.001), lasting mean 6 days (range 1-14 days). They developed chronic arthritic disability (range 1-6 months). Leucopenia was common to both Chikungunya - Dengue fever patients. However, thrombocytopenia was more pronounced in the Dengue patients (mean (SD) platelet count 75 (34)x10(9)/l) than in the Chikungunya patients (117 (70)x10(9)/l) (p = 0.001). In the Chikungunya group there was a positive correlation between duration of the illness - the platelet count (r = 0.181, p = 0.194), but the Dengue group showed a negative correlation (r = -0.309, p<0.001). Most of the clinical - laboratory features of patients with Chikungunya - Dengue fever are similar. Arthritis is the pathognomonic sign in patients with Chikungunya fever.

Imprenta: Postgraduate Medical Journal, v. 85, n. 1005, p. 342-346, 2009

Identificador do objeto digital: 10.1136/pgmj.2007.066746

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Serology ; Chikungunya virus - Viral infections ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology

Data de publicação: 2009