Comparative pathogenesis of epidemic and enzootic Chikungunya viruses in a pregnant Rhesus macaque model
Autor(es): Chen Ching-I, Clark David C, Pesavento Patricia, Lerche Nicholas W, Luciw Paul A, Reisen William K, Brault Aaron C
Resumo: Since 2004, an East African genotype of Chikungunya virus (CHIKV) has emerged, causing significant epidemics of an arthralgic syndrome. In addition, this virus has been associated for the first time with neonatal transmission - neurological complications. In the current study, pregnant Rhesus macaques were inoculated with an enzootic or epidemic strain of CHIKV to compare pathogenesis - transplacental transmission potential. Viremias were similar for both strains - peaked at 2-3 days post-inoculation (dpi). Viral RNA was detected at necropsy at 21 dpi in maternal lymphoid, joint-associated, - spinal cord tissues. The absence of detectable viral RNA - the lack of germinal center development in fetuses indicated that transplacental transmission did not occur. Neutralizing antibodies were detected in all dams - fetuses. Our study establishes a non-human primate model for evaluating vaccines - antiviral therapies - indicates that Rhesus macaques could serve as a competent enzootic reservoir.
Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 83, n. 6, p. 1249-1258, 2010
Identificador do objeto digital: 10.4269/ajtmh.2010.10-0290
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Antibodies ; Chikungunya virus - Cytokines ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2010
